HEPCIDIN: Neue Publikation im "American Society of Hematology"
Dr. Drakesmith vom MRC Weatherall Institute of Molecular Medicine, Universität Oxford, UK, hat uns informiert, dass diese neue Publikation über Hepcidin vom Fachmagazin "American Society of Hematology" akzeptiert wurde.
In dieser Studie wurde der DRG Kit Hepcidin-25 bioactive ELISA (EIA-5258) verwendet.
Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait
Authors:
Emma Jones, Sant-Rayn Pasricha, Angela Allen, Patricia Evans, Chris A. Fisher, Katherine Wray, Anuja Premawardhena, Dyananda Bandara, Ashok Perera, Craig Webster, Pamela Sturges, Nancy F. Olivieri, Timothy St. Pierre, Andrew E. Armitage, John B. Porter, David J. Weatherall, Hal Drakesmith
Key points:
- Expanded erythropoiesis strongly drives hepcidin suppression in severe transfusion-dependent HbE β-thalassemia.
- β-thalassemia carriers, but not HbE carriers, have enhanced erythropoiesis associated with mildly suppressed hepcidin.
Abstract
HbE β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of thalassemia carriage on hepcidin is also unknown, but could be relevant for iron supplementation programs aimed at combating anemia. In 69 Sri Lankan HbE β-thalassemia patients with moderate or severe phenotype, hepcidin was suppressed in 62/69 patients, and overall hepcidin inversely correlated with iron accumulation. On segregating by phenotype, there were no differences in hepcidin, erythropoiesis or hemoglobin between severe or moderate disease, but multiple linear regression showed that erythropoiesis inversely correlated with hepcidin only in severe phenotypes. In moderate disease, no independent predictors of hepcidin were identifiable; nevertheless the low hepcidin levels indicate a significant risk of iron overload. In a population survey of Sri Lankan schoolchildren, β-thalassemia (but not HbE) trait associated with increased erythropoiesis and mildly suppressed hepcidin, suggesting an enhanced propensity to accumulate iron.
In summary, the influence of erythropoiesis on hepcidin suppression associates with phenotypic disease variation and pathogenesis in HbE β-thalassemia, and indicates the epidemiology of β-thalassemia trait requires consideration when planning public health iron interventions.
Accepted December 2, 2014; Copyright © 2014 American Society of Hematology
Hier finden Sie weitere Informationen zur Publikation:
- http://www.bloodjournal.org/content/early/2014/12/17/blood-2014-10-606491
- http://www.ncbi.nlm.nih.gov/pubmed/25519750